01:694:492 Gene Regulation in Cancer & Development
This course may be used to fulfill the elective requirements of the Biological Sciences major.
Pre- or Corequisites
01:694:407-408 or 01:447:384-385 or 11:115:403-404 or 11:126:481
Gene Regulation in Cancer and Development (01:694:492) is a course for advanced undergraduate students majoring in the Life Sciences. Molecular biology is an experimental science, and a major goal of this course is to explain not just what molecular biologists know, but how they know it. Thus, while covering selected topics in gene regulation, development, and cancer, we will emphasize the methods, experimental design, history, and deductive reasoning that has led to the current state of understanding of these topics.
Syllabus (subject to revision):
1 Irvine Course Introduction & Review of some fundamental concepts in Molecular Biology
2 Steward Drosophila as a model system: genetics and development
3 Steward Induction of mutations and analysis of mutant phenotypes
4 Steward Genomics and micro RNAs
5 Steward Control of gene expression in development: activated and repressed promoters
6 Edery Circadian rhythms: overview and principles
7 Edery Clock Mechanisms I
8 Edery Clock Mechanisms II
9 Edery Circadian rhythms and connection to cancer and other diseases I
10 Edery Exam 1 (covers lectures 1-9 & readings)
11 Steward Prenatal diagnosis/ Inherited diseases in humans
12 Steward Gene therapy
13 Steward Personalized genomics
14 Steward TBD
15 Edery Circadian rhythms and connection to cancer and other diseases II
16 Edery Signaling to and from the clock I
17 Edery Signaling to and from the clock II
18 Edery TBD
19 Steward Exam 2 (covers lectures 11-18 & readings)
20 Irvine Introduction to signal transduction and Wnt signaling
21 Irvine Genetic approaches toward identifying & ordering genes in a pathway
22 Irvine Extracellular Regulation of Wnt Signaling
23 Irvine Biochemical & Cell biological analysis of cytoplasmic & nuclear events in Wnt Signaling I
24 Irvine Biochemical & Cell biological analysis of cytoplasmic & nuclear events in Wnt Signaling II
Irvine Take Home handed Out
25 Irvine Downstream of Wnt Signaling: Transcriptional responses & Cellular Outcomes
26 Irvine Wnts, Stem cells, and Cancer Irvine Take Home Due
27 Irvine Wnts & PCP
28 Irvine Hallmarks of Cancer & Review
29 Irvine Exam 3 (covers lectures 20-28 & readings)
Course Satisfies Learning Goals
1. Students should demonstrate an understanding of the knowledge that is needed to begin biomedical research and that is required for post-graduate exams and studies.
2. Students should demonstrate the ability to find and evaluate information about specific biological systems or problems.
Exams, Assignments, and Grading Policy
There will be three exams over the semester that will cover the material presented in class; there will not be a cumulative final exam. Each exam will count for 25% of the grade. In addition, there will be problem sets, in class quizzes, and/or other assignments that together will count for the remaining 25% of the grade. Absence from exams will be excused only in the case of serious illness or family emergency, and only when backed up by appropriate documentation. Requests for regrades must be submitted within 72 hours of return of the exam.
Because we are focusing on current topics, there is no textbook, but there will be assigned readings and literature research from the primary literature, and where appropriate, background reference material will be recommended by the instructors.
The course will be taught by three faculty members from the Department of Molecular Biology and Biochemistry, Drs. Isaac Edery, Ken Irvine and Ruth Steward, plus some guest lecturers.
** All information is subject to change at the discretion of the course coordinator.